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Tricyclic nucleoside analogues as antiherpes agents

Authors
Journal
Antiviral Research
0166-3542
Publisher
Elsevier
Publication Date
Volume
71
Identifiers
DOI: 10.1016/j.antiviral.2006.05.004
Keywords
  • Herpes Simplex Viruses
  • Antivirals
  • Acyclovir
  • Ganciclovir
  • Tricyclic Analogues
  • Fluorescence
Disciplines
  • Chemistry

Abstract

Abstract Tricyclic (T) guanine analogues are a class of compounds in which the N1 and N 2 atoms of the guanine system are linked by etheno bridge to form the 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine system. Almost 70 tricyclic derivatives of guanine-type potent antiherpetic agents acyclovir (ACV), ganciclovir (GCV) and 9-{[cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine were synthesized and evaluated for activity against viruses of the herpes family. Here, we review the most successful compounds in terms of their antiviral activity and physico-chemical properties. These features are modulated by the kind and position of additional substituents present in the appended third ring of aglycone. The best antiherpetic activity–fluorescence combinations as well as activity of compounds in comparison to parent congeners are summarized. The data presented indicate that compounds of the 6-(4-RPh) family are of particular importance because of their advantageous antiviral potency, increased lipophilicity and good or moderate fluorescence properties.

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