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IGFBP-5 as a biomarker of de-differentiation in hepatocytes

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  • Bioengineering

Abstract

Strathprints Institutional Repository Large, Emma and Henderson, Catherine and Flint, David and Grant, Mary (2011) IGFBP-5 as a biomarker of de-differentiation in hepatocytes. [Proceedings Paper] Strathprints is designed to allow users to access the research output of the University of Strathclyde. Copyright c© and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (http:// strathprints.strath.ac.uk/) and the content of this paper for research or study, educational, or not-for-profit purposes without prior permission or charge. Any correspondence concerning this service should be sent to Strathprints administrator: mailto:[email protected] http://strathprints.strath.ac.uk/ Abstracts / Toxicology Letters 205S (2011) S60–S179 S65 P1016 Metallothionein induction, acetylcholine esterase activity and antioxidantive response as biomarkers of thallium toxicity in Tubifex tubifex (Oligochaeta, Tubificidae) G.A. Kılıc¸ ∗, V. Kılıc¸ Biology, Anadolu University, Eskis¸ehir, Turkey Purpose: Metallothioneins (MTs) are cysteine-rich proteins involved in heavy metal homeostasis/detoxification and radical scavenging. MTs have been widely evaluated as biomarkers of metal contamination for different animal species including the pollution resistant aquatic oligochaeta Tubifex tubifex. However no reports are available about the role of MT in thallium (TI) intoxicated Tubifex worms in correlation with other defences. The present study aims to investigate the effects of sublethal TI concentrations on MT induction, acetylcholine esterase (AChE) activity and antioxidantive response in T. tubifex. Methods: The study was consisted of a control and six experimental groups. Experimental groups were exposed to sublethal doses of TI for 7 and 15 days at 0.0025, 0.005, and 0.01mg/L−1

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