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Olivocerebellar lesions in infants born prematurely

Authors
Journal
Brain and Development
0387-7604
Publisher
Elsevier
Publication Date
Volume
4
Issue
5
Identifiers
DOI: 10.1016/s0387-7604(82)80020-x
Keywords
  • Premature Infant
  • Inferior Olivary Nucleus
  • Cerebellar Hemorrhage
  • Brain Damage
  • Brain Stem Lesion
Disciplines
  • Biology
  • Medicine

Abstract

Clinical and neuropathological studies of 15 prematurely born infants having neuronal loss and astrogliosis in the inferior olivary nucleus were made, comparing these 15 cases with gestational age-matched controls. There was a close relationship between lesions of the inferior olivary nuclei and the presence of cerebellar hemispheric lesions such as cerebellar hemorrhage or loss of Purkinje cells and astrogliosis of the cerebellar white matter. This focal or total olivary neuronal loss associated with gliosis of the inferior olivary nuclei may represent retrograde transsynaptic changes from the cerebellar hemisphere lesions in premature neonates cared for in intensive care units.

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