Abstract Routine determinations of the male and female sex hormones in the urines of menopausal patients may have clinical application in that (a) it may indicate whether male or female sex hormone therapy is needed; (b) aid in explaining a lack of response of certain menopausal patients to the usual estrogenic hormone therapy. A disproportionate amount of either male or female sex hormones may in some patients cause certain menopausal symptoms which may be alleviated by proper endocrine therapy. A correlation between the incidence ot definite “hot flashes” and the estrogenic and androgenic content of the urine appears to exist. Estrone has been found in the urines of patients who have had their ovaries and uterus removed. Correlation of urinary sex hormone assays with clinical results in treatment of the menopause is indicated.