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tert-Butyldiphenylsilylamines: A useful protecting group for primary amines

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
27
Issue
37
Identifiers
DOI: 10.1016/s0040-4039(00)84960-6

Abstract

Abstract The utility of the tert -butyldiphenylsilyl group for protecting primary amines is explored. These derivatives are notably stable to chromatography, basic and hydrolytic reagents, as well as alkylating and acylating reagents. They are smoothly cleaved by mild acid and pyridine-HF.

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