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An efficient large scale resolution of (±)-threo-methylphenidate hydrochloride (Ritalin®hydrochloride)

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
10
Issue
16
Identifiers
DOI: 10.1016/s0957-4166(99)00335-3
Keywords
  • Article

Abstract

Abstract An efficient and large scale preparation of (2 R,2′ R)-(+)- threo-methylphenidate hydrochloride ( 3) by the resolution of (±)- threo-methylphenidate hydrochloride ( 1) salt with O, O′-dibenzoyl- d-(+)-tartaric acid in the presence of 4-methylmorpholine is described.

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