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Studies on the antiglucocorticoid action of 11-deoxysteroids in rat thymocytes: Discrepancies betweenin vivoandin vitroeffects

Authors
Journal
Journal of Steroid Biochemistry
0022-4731
Publisher
Elsevier
Publication Date
Volume
13
Issue
7
Identifiers
DOI: 10.1016/0022-4731(80)90223-x

Abstract

Abstract The antiglucocorticoid activity of progesterone and cortexolone was tested by the thymus involution assay in vivo and the thymocyte viability test in vitro. In vivo, both progesterone and cortexolone potentiated the thymolytic effect of cortisol but had no effect on triamcinolone acetonide-induced thymus involution. In vitro the two 11-deoxy steroids behaved as partial agonists-antagonists when tested alone or in combination with cortisol, but were inactive in combination with triamcinolone acetonide. The results indicate that the effect of progesterone and cortexolone depends on the nature of the glucocorticoid agonist used.

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