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Pathophysiological Roles of PPARγ in Gastrointestinal Epithelial Cells

Authors
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
2008
Identifiers
DOI: 10.1155/2008/148687
Keywords
  • Review Article
Disciplines
  • Biology
  • Medicine

Abstract

Although the highest levels of PPARγ expression in the body have been reported in the gastrointestinal epithelium, little is known about the physiological functions of that receptor in the gut. Moreover, there is considerable controversy concerning the effects of thiazolidinedione PPARγ agonists on the two major diseases of the gastrointestinal track: colorectal cancer and inflammatory bowel disease. We will undertake to review both historical and recently published data with a view toward summarizing what is presently known about the roles of PPARγ in both physiological and pathological processes in the gastrointestinal epithelium.

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