Affordable Access

Publisher Website

Liquid chromatographic–mass spectrometric studies on the in vitro degradation of a poly(ether ester) block copolymer

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
1029
Identifiers
DOI: 10.1016/j.chroma.2003.12.056
Keywords
  • Degradation
  • Hydrolysis
  • Poly(Ether Ester) Block Copolymer
  • Polymers

Abstract

Abstract A detailed study on the in vitro degradation of a poly(ethylene glycol) and poly(butylene terephthalate) (PEOT/PBT) segmented block copolymer was carried out using liquid chromatography/electrospray–mass spectrometry. Accelerated hydrolysis of PEOT/PBT was achieved by placing the material for 14 days in a refluxing phosphate buffered saline (pH 7.4) solution. All major degradation products and several side-products were identified using both the positive and the negative ion mode. The data indicate that degradation does not only occur in the “soft”, but also in the “hard” segments of the polymer. Liquid chromatographic separation is required to distinguish between degradation products with different sequences but identical molecular mass. The addition of ammonium and sodium ions provided important complementary information on the number of monomer units present in the degradation products.

There are no comments yet on this publication. Be the first to share your thoughts.