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Identification of transcriptional regulators in the mouse immune system

Authors
Journal
Nature Immunology
1529-2908
Publisher
Nature Publishing Group
Publication Date
Volume
14
Issue
6
Identifiers
DOI: 10.1038/ni.2587
Keywords
  • Article
Disciplines
  • Computer Science

Abstract

The differentiation of hematopoietic stem cells into immune cells has been extensively studied in mammals, but the transcriptional circuitry controlling it is still only partially understood. Here, the Immunological Genome Project gene expression profiles across mouse immune lineages allowed us to systematically analyze these circuits. Using a computational algorithm called Ontogenet, we uncovered differentiation-stage specific regulators of mouse hematopoiesis, identifying many known hematopoietic regulators, and 175 new candidate regulators, their target genes, and the cell types in which they act. Among the novel regulators, we highlight the role of ETV5 in γδT cells differntiation. Since the transcriptional program of human and mouse cells is highly conserved1, it is likely that many lessons learned from the mouse model apply to humans.

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