Affordable Access

Publisher Website

Dose-response relationship of topically applied mitomycin C for the prevention of laser myringotomy closure

Authors
Journal
Otolaryngology - Head and Neck Surgery
0194-5998
Publisher
SAGE Publications
Publication Date
Volume
129
Issue
5
Identifiers
DOI: 10.1016/s0194-5998(03)01394-9
Keywords
  • Original Article
Disciplines
  • Design

Abstract

Abstract Objective We sought to determine a dose-response curve for topical mitomycin C when used to prolong the patency of laser-assisted myringotomies. Study design and setting Bilateral myringotomies were performed using the argon laser in 40 guinea pigs with normal ears. Pledgets with (0.05, 0.2, 0.4, or 2.0 mg/mL) mitomycin C were applied topically. Monitoring consisted of weekly or biweekly otomicroscopy. Results As in previous studies, all saline-treated myringotomies closed by day 7. By day 14, all myringotomies (100%) in the 0.05 mg/mL group were closed. By contrast, all myringotomies (100%) remained patent in the 0.2 and 0.4 mg/mL treatment groups, and 56% of the myringotomies remained patent in the 2.0 mg/mL group at day 14. By day 56, all myringotomies were closed in the 2.0 mg/mL group, 5 (50%) myringotomies were patent in the 0.4 mg/mL group, and 1 (11%) myringotomy was patent in the 0.2 mg/mL group. The study was terminated on day 84 (12 weeks). At that time, only the 0.4 mg/mL group had patent myringotomies (n = 3; 30%). The highest dose (2.0 mg/mL) of mitomycin was significantly associated with otorrhea. Otorrhea also appeared to be associated with earlier myringotomy closure. Conclusion There is a dose-response curve for topical mitomycin C when used for prolonging myringotomy patency in doses up to 0.4 mg/mL. Higher doses do not appear to prolong patency and are associated with greater otorrhea, suggesting middle ear toxicity.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Dose-response relationship of topically applied mi...

on Otolaryngology - Head and Neck... November 2003

Dose-response relationships for topically applied...

on British Journal of Dermatology April 1990

Dose-response relationship of topically applied me...

on European Journal of Clinical P... 1992

Preventing myringotomy closure with topical mitomy...

on Otolaryngology - Head and Neck... Jan 01, 1999
More articles like this..