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Perineurial sodium-potassium-ATPase activity in streptozotocin-diabetic rats

Authors
Journal
Experimental Neurology
0014-4886
Publisher
Elsevier
Publication Date
Volume
97
Issue
2
Identifiers
DOI: 10.1016/0014-4886(87)90097-5
Disciplines
  • Medicine

Abstract

Abstract Perineurial sodium-potassium-ATPase activity was estimated in streptozotocin-diabetic rats and compared with that in control animals. Total ATPase activity was found to be reduced by 34% and ouabain-sensitive ATPase activity by 53%. This finding is significant in relation to the putative role of the perineurium as a metabolically active perifascicular diffusion barrier that regulates the composition of the endoneurial fluid, as is its possible relevance to the occurrence of endoneurial edema in diabetes.

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