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Fragile X mental retardation protein and synaptic plasticity

Authors
Journal
Molecular Brain
1756-6606
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
6
Issue
1
Identifiers
DOI: 10.1186/1756-6606-6-15
Source
Legacy
Keywords
  • Review
Disciplines
  • Biology

Abstract

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.

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