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Spectrophotometric determination and thermodynamic studies of the charge transfer complexes of azelastine-HCl

Authors
Journal
Bulletin of Faculty of Pharmacy Cairo University
1110-0931
Publisher
Elsevier
Publication Date
Volume
49
Issue
1
Identifiers
DOI: 10.1016/j.bfopcu.2011.07.003
Keywords
  • Azelastine
  • Ca
  • Ddq
  • Tcnq
  • Thermodynamic Studies
Disciplines
  • Pharmacology

Abstract

Abstract Three charge transfer complexes of azelastine as n-donor with π acceptors, dichloro-dicyanobenzoquinone (DDQ), chloranilic acid (CA) and tetracyanoquinodimethane (TCNQ) were prepared in acetonitrile. They yield a radical anions measured at 456, 520 and 841 nm within concentration ranges of 8.0–72, 40–320 and 1.6–14.4 μg mL −1 with good correlation coefficients ( r = 0.9996–0.9998). The molar absorptivities and association constants for the colored products were evaluated using the Benesi–Hildebrand equation. The free energy change (Δ G 0) and the enthalpy of formation (Δ H 0) as well as the entropy (Δ S 0) were determined for the reaction product with TCNQ. The methods were successfully applied to the analysis of azelastine in its pharmaceutical preparations, where no interferences could be observed from the additives commonly present in the eye drops or nasal spray as proved by good mean recoveries of 98.89 ± 1.06–99.54 ± 1.84%. The results were compared, favorably with the manufacturer method and validated according to ICH guidelines.

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