Affordable Access

Publisher Website

Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide

Authors
Journal
International Journal of Molecular Sciences
1422-0067
Publisher
MDPI AG
Publication Date
Volume
12
Issue
12
Identifiers
DOI: 10.3390/ijms12085187
Keywords
  • Article

Abstract

Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversibly converted to nanoribbons by heating. In contrast, Pentagonal-Ala-Trpzip formed irregular aggregates in water.

There are no comments yet on this publication. Be the first to share your thoughts.