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Engineering virtual cardiac tissue.

Authors
Journal
Briefings in Bioinformatics
1467-5463
Publisher
Oxford University Press
Publication Date
Disciplines
  • Biology
  • Mathematics
  • Medicine
  • Pharmacology

Abstract

The kinetics of proteins involved in ion transfer, sequestration and binding in cardiac cells can be modelled to construct a model of the electrical activity of isolated cardiac cells as a system of ordinary differential equations. These cell models may be incorporated into tissue models, which, when combined with histology and anatomy, form virtual tissues. The effects of changes in specific protein expression, or changes in protein kinetics, produced by mutations or pharmacological agents, can be simulated using these tissue models and used to account for the whole organ effects of changes in specific ion-transport protein activity.

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