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Molecular mechanisms of nickel carcinogenesis

Authors
Publisher
Elsevier
Publication Date
Keywords
  • Chim/03 Chimica Generale E Inorganica
Disciplines
  • Ecology
  • Geography

Abstract

Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed.

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