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Design and synthesis of multifunctional phospholipids

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
41
Issue
21
Identifiers
DOI: 10.1016/s0040-4039(00)00596-7
Keywords
  • Solid Phase Synthesis
  • Molecular Recognition
  • Phospholipids
  • Nickel-Chelators
  • Biotin
Disciplines
  • Biology

Abstract

Abstract The synthesis of a bifunctionalized phosholipid capable of binding streptavidin or poly-histidine-tagged proteins is reported for the first time. The head group containing both a biotin and an NTA chelator is synthesized via a new approach using solid phase synthesis.

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