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Point-mutation effects on charge-transport properties of the tumor-suppressor gene p53

Authors
Publisher
American Physical Society
Publication Date
Keywords
  • Qc Physics
  • Rc0254 Neoplasms. Tumors. Oncology (Including Cancer)

Abstract

We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective tight-binding models which simulate hole propagation along the DNA, a statistical analysis of mutation-induced charge transfer modifications is performed. In contrast to noncancerous mutations, mutation hot spots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.

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