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Fatal disseminated herpes simplex virus infection and hemorrhage in the neonate:Coagulation studies in a case and a review

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
76
Issue
3
Identifiers
DOI: 10.1016/s0022-3476(70)80481-4

Abstract

Fatal disseminated herpes simplex virus infection in the neonate was associated with bleeding in 40 per cent of 55 cases. Decreased platelets, prolongation of prothrombin and partial thromboplastin times, absent fibrinogen, increased fibrin degradation products, and decreased activity of factors V and VIII have been demonstrated and suggest the presence of disseminated intravascular coagulation. The contributory role of massive hepatocellular destruction associated with decreased synthesis of coagulation factors must also be considered in the pathogenesis of bleeding in these infants.

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