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Phosphorylation-mediated regulation of signal-dependent nuclear protein transport: The “CcN motif”

DOI: 10.1016/s1874-592x(06)80008-9
  • Biology


Publisher Summary Since the sequence responsible for subcellular localization of the SV40 large tumor antigen (T-ag) has been defined, research in the field of nuclear protein transport has largely revolved around the idea of a nuclear localization signal (NLS) being exclusively responsible for nuclear localization. NLSs have been defined for a multitude of nuclear proteins, and specific NLS-binding proteins or receptors have been identified. The structure and function of NLSs is essentially the same across the plant and animal kingdom, with NLSs from plants, yeasts, and higher mammals being essentially identical. NLSs functional in plants are active in nuclear targeting in yeast cells; yeast NLSs are functional in mammalian cells; and the SV40 T-ag NLS is able to confer nuclear localization on appropriate, normally cytoplasmic carrier proteins in mammalian, insect, yeast, and plant cells.

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