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Effect of ceruletide on epileptogenesis in amygdaloid kindled rats

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
630
Identifiers
DOI: 10.1016/0006-8993(93)90678-g
Keywords
  • Kindling
  • Epilepsy
  • Cck
  • Ceruletide

Abstract

Abstract The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20–80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.

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