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First synthesis of the enantiomerically pure α-hydroxy analogue of S-tert-butyl cysteine

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
8
Issue
1
Identifiers
DOI: 10.1016/s0957-4166(96)00471-5
Disciplines
  • Chemistry

Abstract

We report the first synthesis of enantiomerically pure 2-hydroxy 3- tert-butylthio propionic acid in a one-pot reaction from chiral glycidate with total conservation of stereochemistry. The targeted compound 3 was purified by preparative HPLC and fully characterised for the first time.

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