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Plant Food Allergens: Another Climate Change–Public Health Link

Environmental Health Perspectives
Environmental Health Perspectives
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DOI: 10.1289/ehp.0900670
  • Perspectives
  • Correspondence


Perspectives | Correspondence A 190 volume 117 | number 5 | May 2009 • Environmental Health Perspectives Adverse Health Effects from Combustion-Derived Nanoparticles: The Relative Role of Intrinsic Particle Toxicity and Host Response doi:10.1289/ehp.0800218 It is widely accepted that airborne pollu- tion causes adverse health effects in humans (Gauderman et al. 2007). In addition to the concentration of particulate matter (PM), these effects have been related to innate par- ticle toxicity. Stoeger et al. (2009) recently showed that, with a slope that significantly depends on particle structure, surface, and organic carbon content, combustion-derived nanoparticles behave in a different manner in in vitro systems and when reacting with lung surface (i.e. after particle–lung interaction). We have stressed that mechanistic link- ages between PM and health effects should be investigated in more detail (Cetta et al. 2007, 2008). Here, we would like to comment on the role of the individual response in the occurrence of the clinically evident outcome, that is, how individual charac teris tics of the host, in the presence of the same (or similar) noxious agents, are responsible for or deter- mine the type and the severity of the response. Until now, toxicity has been considered mainly as an intrinsic property of each pollut- ant, depending on size, type, and composition of each particle. Stoeger et al. (2009) focused specifically on structure, BET (Brunauer, Emmett, and Teller) surface area, and oxida- tive potency. Interestingly, they stressed par- ticle–lung interaction and the ability of some particles rich in organic content, namely, soot with high organic content, to determine a higher than expected inflammatory response due to increased cytochrome P450 1A1 induction; they also introduced a new param- eter, inflammatory efficacy, in addition to oxidative potency. In our opinion, this could be just the top of the iceberg. In fact, “oxidative stress” is a w

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