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A7DB: a relational database for mutational, physiological and pharmacological data related to the α7 nicotinic acetylcholine receptor

Authors
Publisher
BioMed Central
Publication Date
Source
PMC
Keywords
  • Database
Disciplines
  • Biology
  • Chemistry
  • Medicine
  • Pharmacology

Abstract

1471-2202-6-2.fm ral ss BioMed CentBMC Neuroscience Open AcceDatabase A7DB: a relational database for mutational, physiological and pharmacological data related to the α7 nicotinic acetylcholine receptor Steven D Buckingham1,2, Luanda Pym2, Andrew K Jones2, Laurence Brown2, Mark SP Sansom1, David B Sattelle2 and Philip C Biggin*1 Address: 1Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU. UK and 2MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX. UK Email: Steven D Buckingham - [email protected]; Luanda Pym - [email protected]; Andrew K Jones - [email protected]; Laurence Brown - [email protected]; Mark SP Sansom - [email protected]; David B Sattelle - [email protected]; Philip C Biggin* - [email protected] * Corresponding author Abstract Background: Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subunits in recent years has been α7. This subunit can form functional homomeric pentamers (α7)5, which can make interpretation of physiological and structural data much simpler. The growing amount of structural, pharmacological and physiological data for these receptors indicates the need for a dedicated and accurate database to provide a means to access this information in a coherent manner. Description: A7DB http://www.lgics.org/a7db/ is a new relational database of manually curated experimental physiological data associated with the α7 nAChR. It aims to store as much of the pharmacology, physiology and structural data pertaining to the α7 nAChR. The data is accessed via web interface that allows a user to search the data in multiple ways: 1) a simple text query 2) an incremental query bu

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