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A convenient protective method for the 7-amino function on a cephem derivative in wittig vinylation

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
35
Issue
51
Identifiers
DOI: 10.1016/0040-4039(94)88521-4

Abstract

Abstract A novel preparative pathway for diphenylmethyl 7 β-amino-3-vinylceph-3-em-4-carboxylate from 3-chloromethyl derivative is described. As a convenient protecting group for the 7-amino function in a Wittig reaction, six membered azine derivatives incorporating the 7-amino group were developed as a surrogate of conventional protecting groups.

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