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Human glucagon-like peptides 1 and 2 activate rat brain adenylate cyclase

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
178
Issue
1
Identifiers
DOI: 10.1016/0014-5793(84)81245-4
Keywords
  • Glucagon-Like Peptide I
  • Glucagon-Like Peptide 2
  • Glucagon
  • Camp
  • Pituitary
  • Hypothalamus
  • Liver Plasma Membrane
Disciplines
  • Medicine

Abstract

Abstract Two human glucagon-like peptides, GLP-1 and GLP-2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit [ 125I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes. Nevertheless, GLP-1 and GLP-2 were each found to be potent stimulators of both rat hypothalamic and pituitary adenylate cyclase. Only 30–50 pM concentrations of each peptide elicited half-maximal adenylate cyclase stimulation. Our data suggest that GLP-1 and GLP-2 may be neurotransmitters and/or neuroendocrine effectors, which would account for their high degree of sequence conservation through vertebrate evolution.

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