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2-Pyridin-2-yl-1H-indole derivatives: synthesis, estrogen receptor binding affinity, and photophysical properties.

Authors
Type
Published Article
Journal
Bioorganic chemistry
Publication Date
Volume
34
Issue
1
Pages
1–14
Identifiers
PMID: 16325224
Source
Medline

Abstract

A series of novel 2-pyridin-2-yl-1H-indole derivatives (4a-f) was prepared by intramolecular cyclodehydration of alpha-anilinyl (or 3-anisidyl)-2-pyridin-2-yl-ethanones (2a-f) and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. These compounds showed long wavelength fluorescent emission, which is sensitive to solvent polarity and pH, while indol-6-ols 4b, e, and f displayed reasonably good binding affinities to ER.

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