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2-(aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents.

Authors
  • Capps, D B
  • Dunbar, J
  • Kesten, S R
  • Shillis, J
  • Werbel, L M
  • Plowman, J
  • Ward, D L
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
Dec 25, 1992
Volume
35
Issue
26
Pages
4770–4778
Identifiers
PMID: 1479579
Source
Medline
License
Unknown

Abstract

2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with [(alkylamino)alkyl]hydrazines. Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia. Advanced studies led to the selection of 3bbb for clinical trial.

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