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1H, 13C and 15N chemical shift assignments of IPSEΔNLS.

Authors
  • Meyer, N Helge
  • Schramm, Gabriele
  • Sattler, Michael
Type
Published Article
Journal
Biomolecular NMR Assignments
Publisher
Springer-Verlag
Publication Date
Oct 01, 2011
Volume
5
Issue
2
Pages
225–227
Identifiers
DOI: 10.1007/s12104-011-9305-6
PMID: 21516468
Source
Medline
License
Unknown

Abstract

The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1) is a major immunogenic component of schistosomes. It potently triggers the release of interleukin-4 from basophilic granulocytes in an IgE-dependent manner, suggesting a key function in the modulation of the host's immune response to Schistosoma mansoni infection. Here we present the near complete assignment of an IPSE/alpha-1 variant, IPSEΔNLS, which comprises the core domain of the protein.

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