Affordable Access

Publisher Website

The interaction of vasoactive substances during exercise modulates platelet aggregation in hypertension and coronary artery disease.

Authors
  • 1
Type
Published Article
Journal
BMC Cardiovascular Disorders
1471-2261
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
8
Pages
11–11
Identifiers
DOI: 10.1186/1471-2261-8-11
PMID: 18505546
Source
Medline

Abstract

Despite the pronounced activation of Sympathetic Nervous System (SNS) and increased TXB2 levels during acute exercise platelet aggregation decreases, possibly to counterbalance the prothrombotic state. Since this effect seems to be mediated by the normal endothelium (through prostacyclin and nitric oxide), in conditions characterized by endothelial dysfunction (hypertension, CAD) reduced platelet aggregation is attenuated, thus posing such patients in increased risk for thrombotic complications.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F