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Diastereoselective synthesis ofsyn-3,5-dihydroxyesters via ruthenium-catalyzed asymmetric transfer hydrogenation

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
43
Issue
14
Identifiers
DOI: 10.1016/s0040-4039(02)00310-6
Keywords
  • Asymmetric Transfer Hydrogenation
  • Syn-Diols
  • Chiral Ru Catalysts

Abstract

Abstract The asymmetric transfer hydrogenation of chiral 5-hydroxy-3-ketoesters in 2-propanol using chlororuthenium(II)arene/β-amino alcohol in situ catalyst combinations or a pre-synthesized Ru-{β-amino alcohol} true catalyst, provides syn-3,5-dihydroxyesters in high yields and up to 80% de.

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