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Pulmonary excretion of carbon monoxide in the human infant as an index of bilirubin production. I. Effects of gestational and postnatal age and some common neonatal abnormalities

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
94
Issue
6
Identifiers
DOI: 10.1016/s0022-3476(79)80231-0
Keywords
  • Fetal And Neonatal Medicine
Disciplines
  • Biology
  • Medicine

Abstract

Using a single pass, flow-through system, the pulmonary excretion rate of endogenously produced carbon monoxide was measured as an index of bilirubin production in human infants with varying gestational and postnatal ages and with a variety of clinical abnormalities. No significant difference in V̇ECO was found related to sex or gestational age. The mean V̇ECO for a small group of Oriental infants was significantly increased. V̇ECO decreased with increasing postnatal age. As expected, infants with hemolytic disease of the newborn had a markedly increased mean V̇ECO. Infants with jaundice of unknown etiology also had an elevated mean V̇ECO, implying that increased bilirubin production may be a factor contributing to the “nonphysiologic” bilirubinemias of these infants.

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