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Microwave-assisted synthesis of N1- and C3-substituted pyrazolo[3,4-d]pyrimidine libraries

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
52
Issue
44
Identifiers
DOI: 10.1016/j.tetlet.2011.08.103
Keywords
  • Pyrazolo[3
  • 4-D]Pyrimidines
  • Pd-Catalyzed Cross Coupling
  • Mitsunobu Reaction
  • Microwave-Assisted Synthesis
  • Library Synthesis

Abstract

Abstract The parallel synthesis of a library N1- and C3-substituted-pyrazolo[3,4- d]pyrimidines is described. The microwave-assisted approach involves the de novo generation of the heterocyclic scaffold, facile alkylation at N1 via either a Mitsunobu or a direct alkylation reaction and arylation at C3 via a Suzuki reaction.

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