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Are Ly-1 B cells important in autoimmune disease?

Authors
Journal
Journal of Autoimmunity
0896-8411
Publisher
Elsevier
Publication Date
Volume
2
Identifiers
DOI: 10.1016/0896-8411(89)90134-0
Disciplines
  • Medicine

Abstract

Abstract Although Ly-1 B cells produce autoantibodies and are found at elevated frequencies in certain autoimmune strains, very little is known about the role of these cells, if any, in autoimmune disease. In this publication, we summarize some recent findings relevant to Ly-1 B-cell development, clonal expansion and antibody production. We then consider the idea that Ly-1 B cells constitute the most primitive B-cell lineage in mammals and that the evolutionary niche occupied by these cells requires that they produce a basic set of autoantibodies that cross-react with common bacterial antigens.

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