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Short synthesis of both enantiomers of cytoxazone using the Petasis reaction

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
15
Issue
19
Identifiers
DOI: 10.1016/j.tetasy.2004.08.004

Abstract

Abstract Both enantiomers of cytoxazone, (−)- 1 and (+)- 1, were synthesized using the Petasis reaction of dl-glyceraldehyde 2, 4-methoxyphenylboronic acid 3 and ( R)-1-(1-naphthyl)ethylamine 7, following formation of an oxazolidin-2-one ring.

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