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Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

Authors
Journal
Marine Drugs
1660-3397
Publisher
MDPI AG
Publication Date
Volume
8
Issue
2
Identifiers
DOI: 10.3390/md8020347
Keywords
  • Article
Disciplines
  • Biology
  • Chemistry

Abstract

Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.

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