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Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution

Authors
Journal
Research in Microbiology
0923-2508
Publisher
Elsevier
Publication Date
Volume
155
Issue
5
Identifiers
DOI: 10.1016/j.resmic.2004.01.019
Keywords
  • Antibiotic Resistance
  • Deleterious Mutation
  • Fitness Cost
  • Compensatory Mutation
  • Adaptation

Abstract

Abstract Compensatory mutations, due to their ability to mask the deleterious effects of another mutation, are important for the adaptation and evolution of most organisms. Resistance to antibiotics, antivirals, antifungals, herbicides and insecticides is usually associated with a fitness cost. As a result of compensatory evolution, the initial fitness costs conferred by resistance mutations (or other deleterious mutations) can often be rapidly and efficiently reduced. Such compensatory evolution is potentially of importance for (i) the long-term persistence of drug resistance, (ii) reducing the rate of fitness loss associated with the accumulation of deleterious mutations in small asexual populations, and (iii) the evolution of complexity of cellular processes.

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