Affordable Access

Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels

The Journal of Cell Biology
The Rockefeller University Press
Publication Date
  • Original Article


Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through α1H T channels.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Human myoblast fusion requires expression of funct...

on The Journal of Cell Biology May 14, 2001

Kir2.6 Regulates the Surface Expression of Kir2.x...

on Journal of Biological Chemistr... Mar 18, 2011

Kir2.6 regulates the surface expression of Kir2.x...

on Journal of Biological Chemistr... Mar 18, 2011

Functional expression of inward rectifier potassiu...

on The Journal of Membrane Biolog... 2006
More articles like this..