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Carcinine-β-cyclodextrin derivatives as scavenger entities ofOH radicals and SOD-like properties of their copper(II) complexes

Authors
Journal
Inorganica Chimica Acta
0020-1693
Publisher
Elsevier
Publication Date
Volume
361
Issue
6
Identifiers
DOI: 10.1016/j.ica.2007.01.021
Keywords
  • Copper
  • Cyclodextrin Derivative
  • Carcinine
  • Superoxide Radical
  • Hydroxyl Radical

Abstract

Graphical abstract 6-Deoxy-6-{4-[N-(2-aminoethyl)propaneamide]imidazolyl}cyclohepta amylose (CDcarc) and 6-{3-amine-N-[2-(imidazol-4-yl)ethyl]propaneamide}-6-deoxycyclohepta amylose (CDcrac) were synthesized with the aim to obtain copper(II) complexes able to scavenge superoxide radical. The copper(II) complexes were studied by means of UV–Vis, ESR, CD, ESI-MS spectroscopies to gain information about the species present in solution as function of the pH. The antioxidant activity was assayed against superoxide enzymatically generated and compared with that obtained from copper(II) complex with underivatized carcinine. The hydroxyl radical scavenging ability of these new ligands was also tested.

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