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New insights into the role of T cells in atopic dermatitis and allergic contact dermatitis

Authors
Journal
Trends in Immunology
1471-4906
Publisher
Elsevier
Publication Date
Volume
22
Issue
10
Identifiers
DOI: 10.1016/s1471-4906(01)02004-x
Keywords
  • Research News
Disciplines
  • Medicine

Abstract

Abstract Recently, studies on eczematous skin diseases, such as atopic dermatitis and allergic contact dermatitis, have concentrated on T-cell-mediated immune effector mechanisms. The apoptosis of keratinocytes induced by T cells and mediated by Fas is a crucial event in the transition from activation of the immune system to the manifestation of eczematous dermatitis. Here, we discuss the underlying mechanisms and molecular principles of the T-cell-induced formation of eczema and the focused targeting of these mechanisms by potential therapies.

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