Affordable Access

Publisher Website

CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE

Authors
Journal
Indian Journal of Dermatology
0019-5154
Publisher
Medknow Publications
Publication Date
Volume
56
Issue
2
Identifiers
DOI: 10.4103/0019-5154.80402
Keywords
  • Review Article
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of “hapten concept” in immune sensitization has recently been contested by the “pharmacological interaction” hypothesis. After completion of the “human genome project” and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The study of severe cutaneous drug hypersensitivit...

on Current opinion in allergy and... August 2014

[Rate of cutaneous drug hypersensitivity].

on Allergie und Immunologie 1972

The immunological basis of purpura due to drug hyp...

on Proceedings of the Royal Socie... January 1962

Genetic control of cutaneous basophil hypersensiti...

on Journal of Experimental Medici... Jan 01, 1976
More articles like this..