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Novel chiral phosphine-phosphoramidite ligands derived from 1-naphthylamine for highly efficient Rh-catalyzed asymmetric hydrogenation

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
19
Issue
15
Identifiers
DOI: 10.1016/j.tetasy.2008.07.022

Abstract

Abstract A new chiral phosphine-phosphoramidite ligand ( S)-HY-Phos 1 has been prepared from 1-naphthylamine via a two-step transformation, and successfully applied in the Rh-catalyzed asymmetric hydrogenation of various functionalized olefins, including α-(acetamido)cinnamates, enamides and α-enol ester phosphonates, in which up to 98% ee, 99% ee and 99% ee were achieved, respectively.

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