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Wing Defects in Drosophila xenicid Mutant Clones Are Caused by C-Terminal Deletion of Additional Sex Combs (Asx)

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
4
Issue
12
Identifiers
DOI: 10.1371/journal.pone.0008106
Keywords
  • Research Article
  • Developmental Biology
  • Cell Biology/Cell Adhesion
  • Cell Biology/Developmental Molecular Mechanisms
  • Cell Biology/Gene Expression
  • Cell Biology/Morphogenesis And Cell Biology
  • Developmental Biology/Morphogenesis And Cell Biology
  • Developmental Biology/Organogenesis
Disciplines
  • Biology
  • Design

Abstract

Background The coordinated action of genes that control patterning, cell fate determination, cell size, and cell adhesion is required for proper wing formation in Drosophila. Defects in any of these basic processes can lead to wing aberrations, including blisters. The xenicid mutation was originally identified in a screen designed to uncover regulators of adhesion between wing surfaces [1]. Principal Findings Here, we demonstrate that expression of the βPS integrin or the patterning protein Engrailed are not affected in developing wing imaginal discs in xenicid mutants. Instead, expression of the homeotic protein Ultrabithorax (Ubx) is strongly increased in xenicid mutant cells. Conclusion Our results suggest that upregulation of Ubx transforms cells from a wing blade fate to a haltere fate, and that the presence of haltere cells within the wing blade is the primary defect leading to the adult wing phenotypes observed.

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