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Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis

Authors
Journal
Journal of Neuroimmunology
0165-5728
Publisher
Elsevier
Publication Date
Volume
184
Identifiers
DOI: 10.1016/j.jneuroim.2006.11.015
Keywords
  • Multiple Sclerosis
  • Cns Demyelinating Autoimmune Disease
  • Inflammation
  • Neuron Degeneration
  • Experimental Autoimmune Encephalomyelitis
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions, there has been a major focus on understanding mechanisms of demyelination. However, identification of markers for axonal damage and development of new imaging techniques has enabled detection of subtle changes in axonal pathology and revived interest in the neurodegenerative component of MS. Axonal loss is generally accepted as the main determinant of permanent clinical disability. However, the role of axonal loss early in disease or during relapsing–remitting disease is still under investigation, as are the interactions and interdependency between inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of MS.

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