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The polymorphism of cholinesterases and its physiological significance

Authors
Journal
Trends in Biochemical Sciences
0968-0004
Publisher
Elsevier
Publication Date
Volume
5
Issue
6
Identifiers
DOI: 10.1016/0968-0004(80)90014-6
Disciplines
  • Biology

Abstract

Abstract Acetylcholinesterase and butyrylcholinesterase occur under several molecular forms in vertebrate tissues. In the asymmetric, low-salt aggregating forms, the catalytic subunits are linked to a collagen-like ‘tail’. These molecules appear to be associated with extracellular basal lamina, e.g. in neuromuscular junction. Other tail-less, or globular, forms which are predominant in most tissues of higher vertebrates. include membrane-bound as well as soluble variants. There are clear structural homologies between the various forms of these two enzymes throughout the range of vertebrates. Such a polymorphism probably ensures an optimal functioning of various cholinergic structures.

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