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Catalytic asymmetric ring-opening of bridged tricyclic anhydrides

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
1
Issue
8
Identifiers
DOI: 10.1016/s0957-4166(00)80538-8

Abstract

Abstract Cinchona alkaloid catalysed methanolysis of three different achiral tricyclic anhydrides provides convenient access to either enantiomer of the corresponding half-esters in 35–67% enantiomeric excess; the absolute configuration of the products has been determined and a convenient procedure developed for preparation of multigram quantities of either enantiomer of one half-ester in ∼90% e.e.

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