Affordable Access

Publisher Website

Hypothyroidism after radiotherapy of head and neck cancer

Authors
Journal
Journal of Cranio-Maxillofacial Surgery
1010-5182
Publisher
Elsevier
Volume
42
Issue
4
Identifiers
DOI: 10.1016/j.jcms.2013.09.009
Keywords
  • Head And Neck Cancer
  • Radiotherapy
  • Hypothyroidism
Disciplines
  • Medicine

Abstract

Abstract Aim Hypothyroidism is not commonly considered as a complication of radiotherapy to the head and neck region. The purpose of this retrospective study was to determine the frequency of thyroid dysfunction in patients after radiotherapy, to compare thyroid hormone levels in irradiated patients with Control group and to predict development of thyroid hypofunction in time. Material and method Thyroid function was measured by means of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodthyronine (FT3) in 43 patients who had nonthyroid head–neck carcinomas treated by radiotherapy or radiotherapy in combination with other modalities. These data were compared with hormone levels of 40 Control group patients treated solely by surgery. Results Hypothyroidism was found in 35% of irradiated patients. In comparison with Control group there were significant differences between TSH and FT4 levels, difference between FT3 levels was insignificant. A correlation between hormone levels and follow-up was detected. Conclusion Our results indicate that hypothyroidism is a frequent late side effect of radiotherapy to head and neck. Lifelong monitoring of thyroid function appears to be justified when radiotherapy is a part of treatment protocol.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Hypothyroidism after radiotherapy of head and neck...

on Journal of Cranio-Maxillofacia...

Hypothyroidism after external radiotherapy for hea...

on International Journal of Radia... Sep 01, 1997

How common is hypothyroidism after external radiot...

on Indian Journal of Medical and... Jan 01, 2011

Long-term incidence of hypothyroidism after radiot...

on International Journal of Radia... Oct 01, 2004
More articles like this..