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Differentiation of mucopolysaccharidoses by analyses of the excreted sulfated mucopolysaccharides

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
80
Issue
3
Identifiers
DOI: 10.1016/0009-8981(77)90150-4

Abstract

Abstract Analyses of sulfated mucopolysaccharides excreted by patients with Hunter, Hurler, Scheie, Sanfilippo A and Sanfilippo B syndromes are reported. Three distinct methods, namely agarose gel electrophoresis, enzymatic degradation and molecular weight determination, were used in an attempt to differentiate the mucopolysaccharidoses by analysis of the urinary mucopolysaccharides. It is shown that by the combination of these methods it is possible to differentiate most of the syndromes and also to demonstrate that some patients with the same syndrome excrete different types of sulfated mucopolysaccharides.

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