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Primary immune response of guinea pig spleen cells in vitro

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
20
Identifiers
DOI: 10.1016/0022-1759(78)90251-x

Abstract

Abstract Spleen cells of the primed guinea pig, when cultured alone, failed to make a primary immune response against heterologous erythrocytes. When supplemented with lymphocytes obtained from mineral oil induced peritoneal exudate (PEL), a primary immune response against sheep, horse and chicken RBC was obtained. The kinetics, dose response and requirement of PELs for this response are reported.

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